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Quinolinic acid contributes to increased release of glutamate from glutamatergic neurons while simultaneously inhibiting its uptake by astrocytes

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While GLP-1 medications may seem relatively new to the market, theyve actually been used for the treatment of Type 2 diabetes since 2005, when Byetta became the first FDA-approved GLP-1 medication

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Not that this has not been demonstrated before but to my surprise the questions on thyroid tumors and GLP-1 RA keep coming especially from non-endocrinologists This was a huge study that included a total of 460,032 users of GLP-1RAs, 717,792 users of SGLT2is, 2,055,583 users of DPP-4is, and 1,119,868 users of SUs GLP-1RA exposure was not associated with an increased risk of thyroid tumors compared with SGLT2is, DPP-4is, or SUs (meta-analysis: GLP-1RA vs