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Itskovits et al , 2018

These work separately from the gut version and are part of how your brain decides you've had enough to eat

Detection of DNA strand breaks in individual apoptotic cells by the in situ terminal deoxynucleotidyl transferase and nick translation assays

Most people get enough B12 from food, but people who dont eat animal products (vegans/vegetarians), older adults, or those with digestive issues can become deficient