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Mild side effects Examples of the most common mild side effects that can occur with both Humalog and NovoLog (when taken individually) include: injection site reactions, such as pain, redness, itchiness, or swelling around the area of your injection lipodystrophy (skin thickening or pitting around the injection site) rash itching swelling of your feet or ankles weight gain Serious side effects Examples of serious side effects that can occur with both Humalog and NovoLog (when taken individually) include: hypoglycemia (low blood sugar) severe allergic reaction hypokalemia (a low level of potassium in your blood) Effectiveness The only conditions both Humalog and NovoLog are used to treat are type 1 and type 2 diabetes

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