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As seen in Table 1, 73.4% of patients had been using pens for 19 years, 10.6% patients for less than 1 year and 16% for over 9 years

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However, opioids do not reduce inflammation, repair tissue, or restore function and with ongoing use, they often worsen pain physiology (35)

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177 Alvarado TF, Puliga E, Preziosi M, Poddar M, Singh S, Columbano A, et al