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Synergy is inferred from the individual mechanisms, not demonstrated in combination: GHK-Cu: Cosmetically Focused Clinical Data Split-face human dermatology trials on wrinkle depth and skin density (n usually under 50 per arm) Microarray gene mapping (4,000+ genes)

[DOI] [PMC free article] [PubMed] 171.Wu F., Koenig K.L., Zeleniuch-Jacquotte A., Jonas S., Afanasyeva Y., Wjcik O.P., Costa M., Chen Y