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The STEP program studied semaglutide for weight management ( The New England Journal of Medicine , 2021), while SURMOUNT (NEJM, 2022) and SURMOUNT-OSA (NEJM, 2024) examined tirzepatide for weight and for obstructive sleep apnea

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In HG-induced mouse renal podocytes (MPC5) and STZ-induced C57BL/6 mouse models, the LncRNA SNHG17 was found to be elevated in DM mice and HG-treated MPC5, and further studies revealed that lncRNA SNHG17 knockdown reduced podocyte apoptosis by regulating Mst1 degradation and promoting Parkin-dependent mitophagy [114]