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PMID 18042717

Tesofensine, conversely, works in the brain as a triple monoamine reuptake inhibitor, affecting serotonin, norepinephrine, and dopamine to suppress appetite

One study, which also evaluated cognitive function in patients with high MMA concentrations, found no significant effects on the MDD inventory score, but only 30 of the 140 subjects had depression at baseline, which may have diluted any benefits

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