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One characteristic feature of PD pathology has been the selective vulnerability of specific neurons to develop LBs and LNs and subsequent death while sparing others in close anatomical contact with degenerating neurons

In addition to providing long-term weight loss and possibly remission of T2DM, bariatric surgery is not feasible for large populations, has specific indications, and may result in surgical complications as well as other issues like malabsorption and micronutrient deficiencies

Many of these changes are regulated by pathways downstream of glutamine, for instance, DNA methylation can be reversed through the removal of oxidised methylated bases by TET proteins, which require KG (Ito et al, 2011)