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Eligibility criteria Inclusion criteria for original articles encompassed: (1) interventional studies (clinical trials, randomized controlled trials) evaluating gastrointestinal adverse events associated with GLP-1 RAs in non-diabetic patients with overweight or obesity

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For example, Topamax at doses of 200mg daily or higher can reduce the effectiveness of combined hormonal contraceptives, and women of childbearing potential must use highly effective contraception as part of the Pregnancy Prevention Programme

However, its efficacy is reduced by several commonly reported factors

The supernatant was collected and doubly filtered (with a glass filter and then with a PVDF filter)