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Similarly, metabolomic profiling has uncovered specific metabolites that correlate with impaired sperm function, suggesting that these metabolic changes could serve as indicators of reproductive health (164)

The regulatory picture varies by compound: FDA-approved peptides (semaglutide, tirzepatide) are available by prescription with full manufacturing oversight, adverse event reporting, and post-market surveillance

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To further assessment, Vutiglabridin (30 mg/kg) and semaglutide (3 nmol/kg) were administered for 4 weeks before monitoring discontinuation responses for 21 days