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doi: 10.1038/s41598-022-24924-w 14 KomatsuNOkamotoKSawaSNakashimaTOh-horaMKodamaTet al

Shelley Balls, M.D.A., R.D.N., L.D.N., is a registered dietitian at Consumer Health Digest and the owner of Fueling Your Lifestyle, a private-practice nutrition service

This is not merely additive: the MOTS-c may amplify or extend the mitochondrial biogenesis signal beyond what training alone achieves, particularly in older adults whose endogenous MOTS-c response to exercise is blunted [2]

Regarding depression, LPS exposure can induce typical sickness behavior, including anhedonia and reduced activity, which is consistent with clinically observed post-infection depression (Bufalino et al., 2013)