The IPGTT was measured twice, at the end of the modeling and after the semaglutide intervention
A linear gradient of mobile phases was employed, where solvent A comprised 0.1% (v/v) formic acid (##1209246, Sigma Aldrich, Germany) and solvent B consisted of 80% (v/v) acetonitrile (##741857, Sigma Aldrich, USA) with 0.1% (v/v) formic acid
Note: Measuring internal resistance with specialized equipment provides the most reliable indication of true discharge capability
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Conditions such as malabsorption or gastrointestinal disorders can hinder the absorption of B12 from oral supplements
