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In the oral cavity, a unique feature to be handled by the host defence is that continuously replaced bacteria may obtain a firm anchorage on the nonshedding tooth surface and will thereby remain in close contact with the soft tissues surrounding the tooth for a long time and evoke inflammation (1, 2)

doi: 10.18632/oncotarget.13189 87 PinelliNRHurrenKM

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The post says metformin reduces hepatic glucose production and improves insulin sensitivity, while tirzepatide activates GLP-1 and GIP receptors to enhance insulin secretion, reduce appetite, and slow gastric emptying

Angeli JPF, Freitas FP, Nepachalovich P, Puentes L, Zilka O, Inague A