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Mol Metab 18:314 Holst JJ, Wewer Albrechtsen NJ, Pedersen J, Knop FK (2017) Glucagon and amino acids are linked in a mutual feedback cycle: the liver--cell axis

Interestingly, the OB is not only a metabolic sensor but also participates in the control of energy balance: CRISPR gene editing to enhance the excitability of MCs in DIO mice resulted in improved glucose tolerance 34 and these neurons also control the cephalic phase of insulin release 16

A GLP-1 receptor agonist essentially mimics this natural hormone, but it stays in your system much longer than the hormone your body produces on its own