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First-Pass Metabolism and Gastric ADH Activity A small fraction of ingested ethanol undergoes first-pass metabolism in the gastric mucosa before reaching systemic circulation

21 In a randomized placebo-controlled trial in 31 people with rosacea being treated with minocycline (Minocin), the addition of 320 mg GLA twice daily for eight weeks resulted in greater improvement in skin hydration, higher likelihood of achieving treatment success, and better patient satisfaction

IM up to 3/week provides less frequent, moderate dosing

Green R, et al