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SELECT Trial NEJM 2023 Most side effects are manageable and reduce over time Clinical trials show 7580% of patients who experience GI side effects see significant improvement after the first 48 weeks

[DOI] [PubMed] [Google Scholar] 27.Khoo J., Hsiang J.C., Taneja R., Koo S.H., Soon G.H., Kam C.J., Law N.M., Ang T.L

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Interestingly, the benefit of liraglutide for tau phosphorylation in diabetic mice cannot be replicated by insulin treatment, suggesting that the unique neuroprotective effects of GLP-1RAs are medicated by pathways other than insulin signaling pathways [62]