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Although most studies suggest that GLP-1RAs promote weight loss mainly due to their inhibitory effect on food intake, other central effects that have been described for native GLP-1 and some GLP-1RAs in rodents and humans encourage future clinical trials to explore additional mechanisms that potentially underlie the beneficial effects observed with this drug class

Evidence and Safety Many patients prescribed GLP-1 receptor agonists for type 2 diabetes or weight management wonder whether these medications might weaken their immune defences

Strengths include its pragmatic, head-to-head crossover design, which allows within-patient comparisons and direct ranking of therapies in real-world settings, and inclusion of multiple common regimens enhancing external validity

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