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1.2 Important Limitations Because of the risk to the fetus of decreased IQ, neurodevelopmental disorders, neural tube defects, and other major congenital malformations, which may occur very early in pregnancy, valproate should not be used to treat women with epilepsy or bipolar disorder who are pregnant or who plan to become pregnant unless other medications have failed to provide adequate symptom control or are otherwise unacceptable

221 Although the effects of vitamin D supplementation on the course of CKD are still unknown, it may play a role in mitigating certain CKD complications

Understanding these differences allows researchers to make informed decisions when designing studies and selecting peptide formats.

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