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aureus in MC-deficient Kit Wsh/Wsh mice and corresponding wild type (WT) littermates or reconstitution of MC-deficient mice with MCs derived from WT mice showed that (a) In Kit Wsh/Wsh mice recruitment of neutrophils and elimination of bacteria were impaired, (b) reconstituting the MC population in Kit Wsh/Wsh mice by injection of MCs from WT mice could restore their ability to eliminate the bacteria, and (c) exogenous TNF- could compensate the partial ineffectiveness of MC-deficient mice in recruiting neutrophils to the cite of infection supporting the notion that MC-released TNF- participates actively in microbial defense [21] (Fig

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Studies estimate 4060% of an oral dose reaches systemic circulation, with inter-individual variation driven by cytochrome P450 enzyme polymorphisms

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