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Tirzepatide has a half-life of approximately five days, meaning it takes roughly five half-lives, about 25 days, for the medication to be substantially cleared from the system

This article examines the available evidence, explores potential mechanisms that might influence mood during treatment, and provides practical guidance for patients experiencing emotional changes whilst taking this medication

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For autoimmune patients, particularly those with Hashimoto's, this approach can trigger acute inflammatory responses that worsen the very symptoms the medication is meant to address