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It is not a general guideline but has been produced to help doctors make the right decision about treatment during the lock-down period
Ahmed-Sorour H, Bailey CJ (1981) Role of ovarian hormones in the long-term control of glucose homeostasis, glycogen formation and gluconeogenesis
Protocol 1: the slow and steady semaglutide escalation Goal: Minimize side effects while reaching effective therapeutic levels Schedule: Weeks 1-6: 0.25 mg weekly (extended from standard 4 weeks) Weeks 7-12: 0.5 mg weekly (extended) Weeks 13-16: 1.0 mg weekly Weeks 17-20: 1.7 mg weekly Week 21+: 2.4 mg maintenance Why the plotter supports this: By extending the initial low-dose phases to six weeks instead of four, you ensure complete steady state establishment before escalation
Common adverse effects include gastrointestinal symptoms such as nausea, vomiting, and diarrhea, which typically diminish over time