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According to studies, severe oxidative stress occurs in migraine and headache

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T., Dalle Carbonare, L., Zipeto, D

MOTS-c is a mitochondrial-derived peptide that translocates to the nucleus under metabolic stress, activating AMPK-dependent pathways that enhance glucose metabolism, fatty acid oxidation, and mitochondrial biogenesisthe core metabolic adaptations of endurance training

CGRP enhances the transformation of M0 macrophages into M2 macrophages, the anti-inflammatory, pro-regenerative phenotype