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Prescriptions for compounded tirzepatide, when available, may be prescribed as an alternative to commercially unavailable branded medications on the FDA shortage list

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The hypermethylation of progesterone receptor (PGR) gene in luteal cells leads to receptor expression loss which impairs hormone response and breaks down the regulatory feedback needed for sustained hormone production (184)

A 2023 study in Thyroid found that patients initiating GLP-1 agonists while on stable levothyroxine doses required TSH re-checks at 6 to 8 weeks, with approximately 15% needing a dose increase