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Second, it raises the question of where the ceiling lies, and whether further receptor additions (such as amylin or FGF21 agonism, both under investigation in combination compounds) will continue the upward trend

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By activating GLP-1 receptors, Semaglutide enhances insulin secretion in response to meals, suppresses glucagon release (a hormone that raises blood sugar levels), and slows gastric emptying

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