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While anxiety is not an established side effect of Zepbound, patients and clinicians should remain vigilant for other potential mental health changes during treatment

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5961 The most prominent GLP-1R signaling pathway stimulates adenylyl cyclase, leading to increased concentrations of cyclic adenosine monophosphate (cAMP) and the subsequent activation of protein kinase A (PKA)

For patients, this is potentially good news because this itch can be so bad that it disrupts sleep, causes extreme fatigue, and ruins quality of life, yet there are very few treatments for it