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Fourteen were RCTs, including one crossover trial, 21 and one trial was open label

17 Obesity Obesity is a major contributing factor for CKD, explained in part by the observation that obesity predisposes individuals to diabetes and hypertension

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[16] [17] Currently, there are no specific FDA-mandated bone density monitoring requirements for patients prescribed GLP-1 receptor agonists, as these medications have not been definitively linked to increased fracture risk or clinically significant bone loss in regulatory reviews

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