In discussions around GLP 1 therapies, Huberman consistently points out that while pharmacology can drive significant fat loss, long term outcomes still depend on training, nutrition, and lifestyle structure
Proposed pathways include modulation of multiple neurotransmitter systems (influencing serotonin, dopamine, norepinephrine, GABA, glutamate levels), possible involvement of NMDA receptors, alpha-1 adrenergic signaling (e.g., potentiating pineal acetyltransferase activity), inhibition of somatostatin release via dopaminergic routes, reduced ACTH/cortisol for stress buffering, and stimulated growth hormone or somatoliberin secretion
Kurtzman, N
That delay is dangerous because the differential diagnosis includes conditions that can require urgent treatment, including: Giant cell arteritis (vision- and life-threatening) Retinal detachment Central retinal artery occlusion Optic neuritis Acute angle-closure glaucoma Stroke-related visual pathway events The correct pathway is not wait and see. The correct pathway is urgent evaluation by emergency services or immediate ophthalmology or neuro-ophthalmology assessment
FINO2 initiates ferroptosis through GPX4 inactivation and iron oxidation
