Signals from dural perivascular neurons instigate a sequence of events that lead to the release of inflammatory mediators, sterile meningeal inflammation, and sensitization of pain-processing brain regions (33)
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Therapeutically, small trials in humans are underway: one randomized trial in mild AD is testing an oral broad-spectrum antibiotic followed by FMT to reset the microbiome [142]
Its influence spans across diverse immune cell types like granulocytes, monocytes, macrophages, dendritic entities, and T lymphocytes (82)
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