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The theoretical mechanism of a GLP-1 patch would involve delivering the active pharmaceutical ingredient through the skin (transdermally) into the systemic circulation

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Chakravarthy and Booth (5) have extended the thrifty gene hypothesis suggesting that survival during the feast-famine cycle the hunter-gatherer selected genes to support a "physical activity cycle" in which cycling of metabolic processes was triggered by the reduction of skeletal muscle glycogen and triglyceride stores