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HA induces ovarian inflammation in PCOS mice by activating the NLRP3 inflammasome, resulting in follicular dysfunction, ovarian fibrosis, and pyroptotic death (146)

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This review synthesizes insights into metal transporters to advance our understanding of their roles in maintaining systemic and brain Mn homeostasis under healthy conditions and their contribution to Mn dysregulation in disease states, particularly neurological disorders

However, context matters: Higher dose, higher effect: Semaglutides greater efficacy likely comes with proportionally more GI effects