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When liraglutide binds to GLP-1R on GABAergic neurons in the NTS, it directly potentiates GABA release and suppresses food intake (Fortin et al., 2020)

In controlled trials, RDN-delivered MNT modestly but meaningfully improves dietary quality, body weight, waist circumference, glycemic control, blood pressure, and blood cholesterol levels [[207], [208], [209], [210]]