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In SURMOUNT-1 , a 72-week Phase 3 double-blind trial in 2,539 adults with obesity (or overweight with a complication) but without diabetes, once-weekly tirzepatide produced mean weight changes of 15.0% (5 mg), 19.5% (10 mg), and 20.9% (15 mg) versus 3.1% with placebo, with 5057% of participants on the higher doses losing at least 20% of body weight

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Lugner M, Sattar N, Miftaraj M, Ekelund J, Franzen S, Svensson AM, Eliasson B

The clinical and mechanistic evidence presented herein supports the concept that ECM remodeling functions not only as a downstream consequence but also as an active driver of disease synergy