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Clinical trials have demonstrated significant weight loss with semaglutide, with studies reporting an average body weight reduction of approximately 13.7% [1]
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The MDL centers on allegations that drugs such as Ozempic, Wegovy, and related GLP-1 therapies can cause non-arteritic anterior ischemic optic neuropathy (NAION), a rare but serious condition that may result in abrupt and permanent vision impairment
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Nausea is a side effect which affects 3050% of patients taking GLP-1R agonists at clinically licensed doses 15 , with higher doses glycemically more effective but consistently associated with unacceptable tolerability 16,17,18,19
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