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GSTs may also bind toxins and function as transport proteins, which gave rise to the early term for GSTs, ligandin

In the recent past, several studies have revealed metal responsive genes and their genetic manipulations have suggested strategies to develop different crop varieties with improved stress tolerance and avoidance

Some chelators, such as D-penicillamine, also cause direct neurotoxicity, likely by crossing the blood-brain barrier and disrupting copper-dependent central nervous system enzymes, impairing energy metabolism, and increasing oxidative stress [245, 246]

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