Important caveat: the human evidence base is thin and largely unreplicated outside the original Russian groups, and most data are preclinical or older clinical work without modern independent confirmation [13]
Exclusion criteria included any current or prior conditions affecting other bodily systems, such as familial hypercholesterolemia, severe cardiovascular and cerebrovascular diseases (e.g., myocardial infarction, stroke, and heart failure), respiratory diseases, infectious diseases, chronic kidney disease, pregnancy, and malignancies
RM-131 (100 g/day, subcutaneous) accelerated gastric emptying in patients with type 1 or 2 diabetes who had upper gastrointestinal symptoms
Joanne et al., 2012)
Lancet (2017) 389(10080):174155