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B cells The overall number of B cells remains relatively stable throughout most of human lifespan, with a decline only observed in advanced old age, long after the initial signs of immune system inefficacy become apparent [345, 346]

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Another study published in the Journal of Clinical Endocrinology & Metabolism found that a GLP-1 agonist was effective in reducing body weight and BMI in obese women with PCOS who were also being treated with metformin, a medication commonly used to treat insulin resistance