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Among the 39 variables, nine had significantly lower concentrations in the COC users with ES 0.3 (Table 1) and included the two parent estrogens (E1 and 17-estradiol), as well as estriol-3-sulphate (E3-3-sulphate), 2&4-hydroxyestradiol-cysteine (2&4-OHE2-Cys), 2&4-hydroxyestrone-glutathione (2&4-OHE1-SG), 4-hydroxyestradiol-1-N7-guanine (4OHE2-1-N7Gua), 16-epiestriol, 16-keto-estradiol, and 2&4-hydroxyestradiol-glutathione (2&4-OHE2-SG)

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