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Shimada K, Skouta R, Kaplan A, Yang WS, Hayano M, Dixon SJ, et al

These counter-regulatory changes induce hyperphagia and a hypometabolic state, which result in tachyphylaxis to anorectic medications and favor weight regain

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Notable are the salt bridges formed between the carboxy terminus of GSH and the side chains of VP1 R216 (protomer B) and VP1 R229 (protomer A), which form the core of a strong positive patch within the I site (Figs

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