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Early trials in men showed that PT-141 produced penile erections in the absence of external stimulation a finding with significant mechanistic implications, as it demonstrated central-pathway arousal independent of peripheral vascular action

Common side effects of GLP-1 agonists While patients generally tolerate GLP-1 agonists well, some may experience side effects, especially when starting treatment

Finding that body weight and body mass index (BMI) were comparable at baseline and remained unchanged in different groups and strata during the study reasonably excludes the possibility that study results were confounded by systematic changes in diet and physical activity introduced during the trial

The duration of phentermine is limited

JAMA 310, 21912194