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J Nucl Med Technol 36(1):4454

This triple mechanism distinguishes retatrutide from existing licensed treatments such as semaglutide (a GLP-1 receptor agonist) or tirzepatide (a dual GLP-1/GIP agonist)

Ingenuity Pathway Analysis showed that compared to vehicle treatment, mGIPR-Ab/P1 treatment of Gipr fl/fl and Glp1r fl/fl mice resulted in negative enrichment in cell cycle regulation, cholesterol biosynthesis, extracellular matrix (ECM) and collagen organization, and immune response and inflammation pathways in both WAT and liver (Fig

Additionally, oxygen- and nitrogen-centered reactive species are known to play crucial roles in regulating healing [2, 5]

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