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Cai [69] also found that celecoxib can slow TSPC aging by activating the canonical Wnt signaling pathway, with Ror2 functioning as a key receptor for Wnt5a in the aging of TSPCs and serving as an important mediator of Wnt5ainduced aging [67]

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120 Upon activation, Nrf2 is shuttled into the nucleus, where it binds to the antioxidant response element and enhances the expression of antioxidant genes