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Successful transdermal medications like nicotine patches or hormone replacement therapy work because these molecules have specific properties: theyre small, fat-soluble, and potent at very low doses

These drugs dont just make animals eat less overallthey fundamentally change how feeding behavior is organized, Ayala said

It also says scientific research demonstrates that physical exercise boosts GLP-1 secretion, and suggests a minimum of 150 minutes of moderate exercise per week

GLP-1s (glucagon-like peptide-1 receptor agonists) are FDA-approved medications used for long-term weight management