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Targeting growth factor and cytokine pathways to treat idiopathic pulmonary fibrosis

doi: 10.1016/j.biochi.2007.01.012

Second, the arginine at position 3 in the native sequence was substituted with leucine (hence R3)

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Also, as an anabolic hormone, insulin promotes fat storage, and chronic hyperinsulinemia, commonly observed in T2DM, further stimulates lipogenesis while suppressing lipolysis, thereby counteracting BW reduction