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idiosyncratic reaction has been associated with ibuprofen, sulindac, phenylbutazone, piroxicam, diclofenac and indomethacin

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Caffeine's phosphodiesterase (PDE) inhibition sustains elevated cyclic AMP (cAMP) levels in adipocyte tissue, prolonging the activation of hormone-sensitive lipase (HSL) and extending the fat release window beyond what hormonal lipolytic signals alone would maintain