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TTP273, Oral (nonpeptide) GLP-1R agonist: improved glycemic control without nausea and vomiting in phase 2

This encouraged the research for a possible action of the peptide in humans suffering from chronic pronounced pain episodes

These agents can affect the intestinal immune system and alter microbial composition via activation of the sympathetic nervous system, through mechanisms such as norepinephrine release, which has been associated with increased levels of bacteria like Escherichia coli [84]