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The peptide's small molecular weight (0.39 kDa) enables it to interact directly with DNA and act as an epigenetic regulatory factor, modulating chromatin structure and gene accessibility in neural tissue

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Recent multi-omics analyses by Cappellani et al., for instance, have provided strong genetic and proteomic evidence linking DR pathogenesis directly to the activation of specific immune pathways, including the complement system and adaptive T-cell responses [53, 58, 59]

For Western blotting, L4L5 spinal cord segments rostral to the injury site were divided into two halves in sagittal plane and immediately frozen in liquid nitrogen

Radiother Oncol