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PMID 20699420

For this interaction to occur, the structural requirement in the enzyme is the presence of a nucleophilic amino acid side-chain close to the glutathione-docking motif and in a crucial position to interact with the electrophilic motif of glutathione acrylate, as shown in Scheme 9

Overexpression of SLC7A11: a novel oncogene and an indicator of unfavorable prognosis for liver carcinoma

Back Bay Life Science Advisors analyzed the first wave of drugs (at Phase 3) poised to change the NASH management paradigm and shape the ambiguous pricing and reimbursement landscape