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The M1 phenotype of microglia is responsible for synthesizing and releasing various cytokines, including prostaglandin E2 (PGE2), CRP, and TNF-alpha, into the bloodstream (Guo et al., 2020)

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Legumes/Beans Beans and other legumes are good sources of calcium and magnesium plus they offer plant-based protein and even some anti-aging antioxidants

However, the potential for side effects and the invasive nature of the procedure make it essential to consider alternatives seriously

The synthesis and remodeling of Acan occurs at early stages of cartilage formation and remains low during the middle and late stages [59,60,61], while Col-2 expression is consistently high throughout the early and late stages of cartilage formation [62]