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Available from: Accessed: 10 Jun 2025 European Medicines Agency (2023) Guideline on clinical investigation of medicinal products in the treatment or prevention of diabetes mellitus

The combination is community-derived from individual-compound research

Retatrutide acts as a triple receptor agonist, simultaneously targeting the three receptors that play crucial roles in metabolic regulation

313,314 In one study, OA was induced in rats by injecting MIA into the knee joint, mimicking the pathological changes of human OA

This corresponds to an increase of ~225% of plasma glucagon when corrected for the change in glucose concentration