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With heterogeneous evidence of the cardiovascular benefit, mortality, and potential risks of intensive glycemic control reported in several recent clinical trials, achieving good blood glucose control without increasing cardiovascular risk factors such as hypoglycemia and body weight gain is becoming more important [3,4,5,6,7]

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Intact AMG 133 shows faster mean clearance than total AMG 133 (0.568 versus 0.367 ml h 1 kg 1 )

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Over 90% of participants on the highest dose achieved at least 5% weight loss, the threshold where metabolic improvements begin